| http://purl.uniprot.org/citations/17267690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17267690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17267690 | http://www.w3.org/2000/01/rdf-schema#comment | "Shrew-1 was previously isolated from an endometriotic cell line in our search for invasion-associated genes. It proved to be a membrane protein that targets to the basolateral membrane of polarized epithelial cells, interacting with E-cadherin-catenin complexes of adherens junctions. Paradoxically, the existence of adherens junctions is incompatible with invasion. To investigate whether shrew-1 can indeed influence cellular invasion, we overexpressed it in HT1080 fibrosarcoma cells. This resulted in enhanced invasiveness, accompanied by an increased matrix metalloprotease (MMP)-9 level in the supernatant, raising the question about the role of shrew-1 in this process. Logic suggested we looked for an interaction with CD147, a known promoter of invasiveness and MMP activity. Indeed, genetics-based, biochemical, and microscopy experiments revealed shrew-1- and CD147-containing complexes in invasive endometriotic cells and an interaction in epithelial cells, which was stronger in MCF7 tumor cells, but weaker in Madin-Darby canine kidney cells. In contrast to the effect mediated by overexpression, small interfering RNA-mediated down-regulation of either shrew-1 or CD147 in HeLa cells decreased invasiveness without affecting the proliferation behavior of HeLa cells, but the knockdown cells displayed decreased motility. Altogether, our results imply that shrew-1 has a function in the regulation of cellular invasion, which may involve its interaction with CD147."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-07-0637"xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-07-0637"xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Boles E."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Boles E."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Jakob V."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Jakob V."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Ruonala M."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Ruonala M."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Schreiner A."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Schreiner A."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Starzinski-Powitz A."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Starzinski-Powitz A."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Suthaus J."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Suthaus J."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Wouters F."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/author | "Wouters F."xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/pages | "1272-1281"xsd:string |
| http://purl.uniprot.org/citations/17267690 | http://purl.uniprot.org/core/pages | "1272-1281"xsd:string |