| http://purl.uniprot.org/citations/17290224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17290224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17290224 | http://www.w3.org/2000/01/rdf-schema#comment | "The C/EBPalpha transcription factor regulates hepatic nitrogen, glucose, lipid and iron metabolism. However, how it is able to independently control these processes is not known. Here, we use mouse knock-in mutagenesis to identify C/EBPalpha domains that specifically regulate hepatic gluconeogenesis and lipogenesis. In vivo deletion of a proline-histidine rich domain (PHR), dephosphorylated at S193 by insulin signaling, dysregulated genes involved in the generation of acetyl-CoA and NADPH for triglyceride synthesis and led to increased hepatic lipogenesis. These promoters bound SREBP-1 as well as C/EBPalpha, and the PHR was required for C/EBPalpha-SREBP transcriptional synergy. In contrast, the highly conserved C/EBPalpha CR4 domain was found to undergo liver-specific dephosphorylation of residues T222 and T226 upon fasting, and alanine mutation of these residues upregulated the hepatic expression of the gluconeogenic G6Pase and PEPCK mRNAs, but not PGC-1alpha, leading to glucose intolerance. Our results show that pathway-specific metabolic regulation can be achieved through a single transcription factor containing context-sensitive regulatory domains, and indicate C/EBPalpha phosphorylation as a PGC-1alpha-independent mechanism for regulating hepatic gluconeogenesis."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601563"xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601563"xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Mandrup S."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Mandrup S."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Kurz E."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Kurz E."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Nerlov C."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Nerlov C."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Bereshchenko O."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Bereshchenko O."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Ermakova O."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Ermakova O."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Garcia-Silva S."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Garcia-Silva S."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Pedersen T.A."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Pedersen T.A."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Porse B.T."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/author | "Porse B.T."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17290224 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |