| http://purl.uniprot.org/citations/17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17292327 | http://www.w3.org/2000/01/rdf-schema#comment | "DLC-1 (deleted in liver cancer-1) is a tumor suppressor gene for hepatocellular carcinoma and other cancers. To characterize its functions, we constructed recombinant adenovirus encoding the wild-type DLC-1 and examined its effects on behaviors of a hepatocellular carcinoma cell line (SNU-368), which does not express DLC-1. Here, we found that restoration of DLC-1 expression in the SNU-368 cells caused an inhibition of cell proliferation with an increase of a subG1 population. Furthermore, DLC-1 overexpression induced disassembly of stress fibers and extensive membrane protrusions around cells on laminin-1. DLC-1 overexpression also inhibited cell migration and dephosphorylated focal adhesion proteins such as focal adhesion kinase (FAK), Cas (p130Cas; Crk-associated substrate), and paxillin. These observations suggest that DLC-1 plays important roles in signal transduction pathway regulating cell proliferation, cell morphology, and cell migration by affecting Rho family GTPases and focal adhesion proteins."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.01.121"xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Kim T.Y."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Jung M."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Bang Y.J."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Kim H.P."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Jong H.S."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/author | "Kim T.Y.'"xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/pages | "72-77"xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/title | "DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://purl.uniprot.org/core/volume | "355"xsd:string |
| http://purl.uniprot.org/citations/17292327 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17292327 |
| http://purl.uniprot.org/citations/17292327 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17292327 |
| http://purl.uniprot.org/uniprot/Q96QB1#attribution-B615860CBA4A836CEB4DEE7D167DB9F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/Q96QB1#attribution-E4679E07280AC889C83A4C89675D21C0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_A8K119-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_A0A384MTV1-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SYX6-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_A8K6L7-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_Q96QB1-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |
| http://purl.uniprot.org/uniprot/#_Q45XF9-mappedCitation-17292327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17292327 |