| http://purl.uniprot.org/citations/1729596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1729596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1729596 | http://www.w3.org/2000/01/rdf-schema#comment | "At least 20 major proteins make up the ribonucleoprotein (RNP) complexes of heterogeneous nuclear RNA (hnRNA) in mammalian cells. Many of these proteins have distinct RNA-binding specificities. The abundant, acidic heterogeneous nuclear RNP (hnRNP) K and J proteins (66 and 64 kDa, respectively, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) are unique among the hnRNP proteins in their binding preference: they bind tenaciously to poly(C), and they are the major oligo(C)- and poly(C)-binding proteins in human HeLa cells. We purified K and J from HeLa cells by affinity chromatography and produced monoclonal antibodies to them. K and J are immunologically related and conserved among various vertebrates. Immunofluorescence microscopy with antibodies shows that K and J are located in the nucleoplasm. cDNA clones for K were isolated, and their sequences were determined. The predicted amino acid sequence of K does not contain an RNP consensus sequence found in many characterized hnRNP proteins and shows no extensive homology to sequences of any known proteins. The K protein contains two internal repeats not found in other known proteins, as well as GlyArgGlyGly and GlyArgGlyGlyPhe sequences, which occur frequently in many RNA-binding proteins. Overall, K represents a novel type of hnRNA-binding protein. It is likely that K and J play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.12.1.164-171.1992"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.12.1.164-171.1992"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Michael W.M."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Michael W.M."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Matunis M.J."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/author | "Matunis M.J."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/pages | "164-171"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/pages | "164-171"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/title | "Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/title | "Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein."xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/1729596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1729596 |
| http://purl.uniprot.org/citations/1729596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1729596 |
| http://purl.uniprot.org/citations/1729596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1729596 |
| http://purl.uniprot.org/citations/1729596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1729596 |