| http://purl.uniprot.org/citations/17296731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296731 | http://www.w3.org/2000/01/rdf-schema#comment | "Minichromosome maintenance (MCM) complex replicative helicase complexes play essential roles in DNA replication in all eukaryotes. Using a tandem affinity purification-tagging approach in human cells, we discovered a form of the MCM complex that contains a previously unstudied protein, MCM binding protein (MCM-BP). MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2; and, conversely, hexameric complexes of MCM2 to MCM7 lacked MCM-BP, indicating that MCM-BP can replace MCM2 in the MCM complex. MCM-BP-containing complexes exhibited increased stability under experimental conditions relative to those containing MCM2. MCM-BP also formed a complex with the MCM4/6/7 core helicase in vitro, but, unlike MCM2, did not inhibit this helicase activity. A proportion of MCM-BP bound to cellular chromatin in a cell cycle-dependent manner typical of MCM proteins, and, like other MCM subunits, preferentially associated with a cellular origin in G(1) but not in S phase. In addition, down-regulation of MCM-BP decreased the association of MCM4 with chromatin, and the chromatin association of MCM-BP was at least partially dependent on MCM4 and cdc6. The results indicate that multicellular eukaryotes contain two types of hexameric MCM complexes with unique properties and functions."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02384-06"xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02384-06"xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Frappier L."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Frappier L."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Nguyen T."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Nguyen T."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Shire K."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Shire K."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Athanasopoulos V."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Athanasopoulos V."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Sakwe A.M."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/author | "Sakwe A.M."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/pages | "3044-3055"xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/pages | "3044-3055"xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/title | "Identification and characterization of a novel component of the human minichromosome maintenance complex."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/title | "Identification and characterization of a novel component of the human minichromosome maintenance complex."xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17296731 | http://purl.uniprot.org/core/volume | "27"xsd:string |