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http://purl.uniprot.org/citations/17300186http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17300186http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17300186http://www.w3.org/2000/01/rdf-schema#comment"The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p, a potent and selective inhibitor of ERK."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.org/dc/terms/identifier"doi:10.1021/jm061381f"xsd:string
http://purl.uniprot.org/citations/17300186http://purl.org/dc/terms/identifier"doi:10.1021/jm061381f"xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Cao J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Cao J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Chen G."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Chen G."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Jacobs M."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Jacobs M."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Xie X."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Xie X."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Aronov A.M."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Aronov A.M."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Tang Q."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Tang Q."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Green J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Green J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Straub J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Straub J."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Baker C."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Baker C."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Germann U.A."xsd:string
http://purl.uniprot.org/citations/17300186http://purl.uniprot.org/core/author"Germann U.A."xsd:string