| http://purl.uniprot.org/citations/17301177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17301177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17301177 | http://www.w3.org/2000/01/rdf-schema#comment | "The subunit composition of GABA(A) receptors is known to be associated with distinct physiological and pharmacological properties. Previous studies that used phospholipase C-related inactive protein type 1 knock-out (PRIP-1 KO) mice revealed that PRIP-1 is involved in the assembly and/or the trafficking of gamma2 subunit-containing GABA(A) receptors. There are two PRIP genes in mammals; thus the roles of PRIP-1 might be compensated partly by those of PRIP-2 in PRIP-1 KO mice. Here we used PRIP-1 and PRIP-2 double knock-out (PRIP-DKO) mice and examined the roles for PRIP in regulating the trafficking of GABA(A) receptors. Consistent with previous results, sensitivity to diazepam was reduced in electrophysiological and behavioral analyses of PRIP-DKO mice, suggesting an alteration of gamma2 subunit-containing GABA(A) receptors. The surface numbers of diazepam binding sites (alpha/gamma2 subunits) assessed by [3H]flumazenil binding were reduced in the PRIP-DKO mice as compared with those of wild-type mice, whereas the cell surface GABA binding sites (alpha/beta subunits, assessed by [3H]muscimol binding) were increased in PRIP-DKO mice. The association between GABA(A) receptors and GABA(A) receptor-associated protein (GABARAP) was reduced significantly in PRIP-DKO neurons. Disruption of the direct interaction between PRIP and GABA(A) receptor beta subunits via the use of a peptide corresponding to the PRIP-1 binding site reduced the cell surface expression of gamma2 subunit-containing GABA(A) receptors in cultured cell lines and neurons. These results suggest that PRIP is implicated in the trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface, probably by acting as a bridging molecule between GABARAP and the receptors."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3155-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3155-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Hirata M."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Hirata M."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Moss S.J."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Moss S.J."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Ishibashi H."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Ishibashi H."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Kominami E."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Kominami E."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Tanida I."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Tanida I."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Mizokami A."xsd:string |
| http://purl.uniprot.org/citations/17301177 | http://purl.uniprot.org/core/author | "Mizokami A."xsd:string |