| http://purl.uniprot.org/citations/17314283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17314283 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the parkin gene are a major cause of autosomal recessive Parkinson's disease. Here we show that the E3 ubiquitin ligase parkin activates signaling through the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) pathway. Our analysis revealed that activation of this signaling cascade is causally linked to the neuroprotective potential of parkin. Inhibition of NF-kappaB activation by an IkappaB super-repressor or a kinase-inactive IKKbeta interferes with the neuroprotective activity of parkin. Furthermore, pathogenic parkin mutants with an impaired neuroprotective capacity show a reduced ability to stimulate NF-kappaB-dependent transcription. Finally, we present evidence that parkin interacts with and promotes degradation-independent ubiquitylation of IKKgamma/NEMO (NF-kappaB essential modifier) and TRAF2 [TNF (tumor necrosis factor) receptor-associated factor 2], two critical components of the NF-kappaB pathway. Thus, our results support a direct link between the neuroprotective activity of parkin and ubiquitin signaling in the IKK/NF-kappaB pathway."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5537-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Winklhofer K.F."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Krappmann D."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Culmsee C."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Tatzelt J."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Nakaso K."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Wegener E."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Henn I.H."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Schlierf A."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Berninger B."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Bouman L."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Schlehe J.S."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/author | "Schramm J.E."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/pages | "1868-1878"xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/title | "Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17314283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17314283 |
| http://purl.uniprot.org/citations/17314283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17314283 |
| http://purl.uniprot.org/uniprot/Q9Y6K9#attribution-5FD61467308F7C6B54F9BF0DD6202EAB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17314283 |
| http://purl.uniprot.org/uniprot/O60260#attribution-14343870D4C4098841ABA459B83CFCF7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17314283 |
| http://purl.uniprot.org/uniprot/Q12933#attribution-5FD61467308F7C6B54F9BF0DD6202EAB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17314283 |