| http://purl.uniprot.org/citations/17329360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17329360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17329360 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila melanogaster body axes are defined by the precise localization and the restriction of molecular determinants in the oocyte. Polarization of the oocyte during oogenesis is vital for this process. The directed traffic of membranes and proteins is a crucial component of polarity establishment in various cell types and organisms. Here, we investigate the role of the small GTPase Rab6 in the organization of the egg chamber and in asymmetric determinant localization during oogenesis. We show that exocytosis is affected in rab6-null egg chambers, which display a loss of nurse cell plasma membranes. Rab6 is also required for the polarization of the oocyte microtubule cytoskeleton and for the posterior localization of oskar mRNA. We show that, in vivo, Rab6 is found in a complex with Bicaudal-D, and that Rab6 and Bicaudal-D cooperate in oskar mRNA localization. Thus, during Drosophila oogenesis, Rab6-dependent membrane trafficking is doubly required; first, for the general organization and growth of the egg chamber, and second, more specifically, for the polarization of the microtubule cytoskeleton and localization of oskar mRNA. These findings highlight the central role of vesicular trafficking in the establishment of polarity and in determinant localization in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02821"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02821"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/author | "Coutelis J.B."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/author | "Coutelis J.B."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/author | "Ephrussi A."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/author | "Ephrussi A."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/pages | "1419-1430"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/pages | "1419-1430"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/title | "Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/title | "Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis."xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/17329360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17329360 |
| http://purl.uniprot.org/citations/17329360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17329360 |
| http://purl.uniprot.org/citations/17329360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17329360 |
| http://purl.uniprot.org/citations/17329360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17329360 |
| http://purl.uniprot.org/uniprot/P16568 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17329360 |
| http://purl.uniprot.org/uniprot/O18334 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17329360 |