| http://purl.uniprot.org/citations/17343909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17343909 | http://www.w3.org/2000/01/rdf-schema#comment | "The specific role played by NCX1, NCX2, and NCX3, the three isoforms of the Na+/Ca2+ exchanger (NCX), has been explored during hypoxic conditions in BHK cells stably transfected with each of these isoforms. Six major findings emerged from the present study: (1) all the three isoforms were highly expressed on the plasma membranes of BHK cells; (2) under physiological conditions, the three NCX isoforms showed similar functional activity; (3) hypoxia plus reoxygenation induced a lower increase of [Ca2+]i in BHK-NCX3-transfected cells than in BHK-NCX1- and BHK-NCX2-transfected cells; (4) NCX3-transfected cells were more resistant to chemical hypoxia plus reoxygenation than NCX1- and NCX2-transfected cells. Interestingly, such augmented resistance was eliminated by CBDMD (10 microM), an inhibitor of NCX and by the specific silencing of the NCX3 isoform; (5) chemical hypoxia plus reoxygenation produced a loss of mitochondrial membrane potential in NCX1- and NCX2-transfected cells, but not in NCX3-transfected cells; (6) the forward mode of operation in NCX3-transfected cells was not affected by ATP depletion, as it occurred in NCX1- and NCX2-transfected cells. Altogether, these results indicate that the brain specifically expressed NCX3 isoform more significantly contributes to the maintenance of [Ca2+]i homeostasis during experimental conditions mimicking ischemia, thereby preventing mitochondrial delta psi collapses and cell death."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ceca.2007.01.006"xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Adornetto A."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Annunziato L."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Boscia F."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Di Renzo G."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Molinaro P."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Scorziello A."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Secondo A."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Valsecchi V."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Sirabella R."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Canzoniero L.M."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/author | "Staiano R.I."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/name | "Cell Calcium"xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/pages | "521-535"xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/title | "BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential."xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/17343909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17343909 |
| http://purl.uniprot.org/citations/17343909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17343909 |
| http://purl.uniprot.org/uniprot/P48768#attribution-24828022E8E0FB62150F0F45BE4EDDC1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17343909 |
| http://purl.uniprot.org/uniprot/P70549#attribution-24828022E8E0FB62150F0F45BE4EDDC1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17343909 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JZK7-mappedCitation-17343909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17343909 |
| http://purl.uniprot.org/uniprot/#_P70549-mappedCitation-17343909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17343909 |