| http://purl.uniprot.org/citations/17353186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17353186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17353186 | http://www.w3.org/2000/01/rdf-schema#comment | "Src-like adaptor protein 2 (SLAP-2) is a hematopoietic adaptor protein previously implicated as a negative regulator of T-cell antigen receptor (TCR)-mediated signaling. SLAP-2 contains an SH3 and an SH2 domain, followed by a unique carboxyl-terminal tail, which is important for c-Cbl binding. Here we describe a novel role for SLAP-2 in regulation of the colony-stimulating factor 1 receptor (CSF-1R), a receptor tyrosine kinase important for growth and differentiation of myeloid cells. SLAP-2 co-immunoprecipitates with c-Cbl and CSF-1R in primary bone marrow-derived macrophages. Using murine myeloid cells expressing CSF-1R (FD-Fms cells), we show that SLAP-2 is tyrosine-phosphorylated upon stimulation with CSF-1 and associates constitutively with both c-Cbl and CSF-1R. In addition, we show that expression of a dominant negative form of SLAP-2 impairs c-Cbl association with the CSF-1R and receptor ubiquitination. Impaired c-Cbl recruitment also correlated with changes in the kinetics of CSF-1R down-regulation and trafficking. CSF-1-mediated differentiation of FD-Fms cells and activation of downstream signaling events was also enhanced in cells stably expressing dominant negative SLAP-2. Together, these results demonstrate that SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701182200"xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701182200"xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "McGlade C.J."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "McGlade C.J."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Debonneville C."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Debonneville C."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Liontos L.M."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Liontos L.M."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Loreto M.P."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Loreto M.P."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Pakuts B."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/author | "Pakuts B."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/pages | "17953-17963"xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/pages | "17953-17963"xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/title | "The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/title | "The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation."xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17353186 | http://purl.uniprot.org/core/volume | "282"xsd:string |