| http://purl.uniprot.org/citations/1736296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1736296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1736296 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosine phosphorylation is controlled by the opposing actions of tyrosine kinases and phosphotyrosine phosphatases (PTPs). src homology 2 domains (SH2) are found in several types of signaling proteins, including some tyrosine kinases. These domains bind phosphotyrosyl proteins and thus help promote signal transduction. Using mixed oligonucleotide-directed polymerase chain reactions, two previously undescribed rat PTP cDNA fragments were generated. Through subsequent screening of rat megakaryocyte and human erythroleukemia libraries, we obtained a full-length coding sequence for one of these fragments. This cDNA, SH-PTP1, encodes a tyrosine phosphatase containing two highly conserved SH2 domains. SH-PTP1, with a 2.4-kilobase mRNA, a predicted open reading frame of 595 amino acids, and a structure suggesting a nontransmembrane protein, is expressed primarily in hematopoietic and epithelial cells. When expressed in Escherichia coli, SH-PTP1 possesses PTP activity. The structure of SH-PTP1 establishes an additional branch of the tyrosine phosphatase family and suggests mechanisms through which tyrosine phosphatases might participate in signal transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.3.1123"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.3.1123"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Rosenberg R.D."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Rosenberg R.D."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Plutzky J."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/author | "Plutzky J."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/pages | "1123-1127"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/pages | "1123-1127"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/title | "Isolation of a src homology 2-containing tyrosine phosphatase."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/title | "Isolation of a src homology 2-containing tyrosine phosphatase."xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1736296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1736296 |
| http://purl.uniprot.org/citations/1736296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1736296 |
| http://purl.uniprot.org/citations/1736296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1736296 |
| http://purl.uniprot.org/citations/1736296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1736296 |