Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

Vascotto F., Lankar D., Faure-Andre G., Vargas P., Diaz J., Le Roux D., Yuseff M.I., Sibarita J.B., Boes M., Raposo G., Mougneau E., Glaichenhaus N., Bonnerot C., Manoury B., Lennon-Dumenil A.M.

Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.

J. Cell Biol. 176:1007-1019(2007) [PubMed] [Europe PMC]

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again