| http://purl.uniprot.org/citations/17401372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17401372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17401372 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1227"xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1227"xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Blacklow S.C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Blacklow S.C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Gordon W.R."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Gordon W.R."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Histen G."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Histen G."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Sanchez-Irizarry C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Sanchez-Irizarry C."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Vardar-Ulu D."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/author | "Vardar-Ulu D."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/pages | "295-300"xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/pages | "295-300"xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/title | "Structural basis for autoinhibition of Notch."xsd:string |
| http://purl.uniprot.org/citations/17401372 | http://purl.uniprot.org/core/title | "Structural basis for autoinhibition of Notch."xsd:string |