| http://purl.uniprot.org/citations/17404841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17404841 | http://www.w3.org/2000/01/rdf-schema#comment | "Peripheral nerve sheath tumors from individuals with Neurofibromatosis Type 1 (NF1) are highly vascular and contain Schwann cells which are deficient in neurofibromin. This study examines the angiogenic expression profile of neurofibromin-deficient human Schwann cells relative to normal human Schwann cells, characterizing both pro-angiogenic and anti-angiogenic factors. Conditioned media from neurofibromin-deficient Schwann cell lines was pro-angiogenic as evidenced by its ability to stimulate endothelial cell proliferation and migration. Using gene array and protein array analysis, we found increased expression of pro-angiogenic factors and decreased expression of anti-angiogenic factors in neurofibromin-deficient Schwann cells relative to normal human Schwann cells. Neurofibromin-deficient Schwann cells also showed increased expression of several growth factor receptors and decreased expression of an integrin. We conclude that neurofibromin-deficient Schwann cells have dysregulated expression of pro-angiogenic factors, anti-angiogenic factors, growth factor receptors, and an integrin. These dysregulated molecules may contribute to the growth and progression of NF1 peripheral nerve sheath tumors."xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11064-007-9279-z"xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/author | "Thomas S.L."xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/author | "De Vries G.H."xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/name | "Neurochem Res"xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/pages | "1129-1141"xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/title | "Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells."xsd:string |
| http://purl.uniprot.org/citations/17404841 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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