| http://purl.uniprot.org/citations/17457011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17457011 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe aim of the present study was to examine whether stanniocalcin 1 (STC1) affects cardiomyocytes under physiological or pathophysiological conditions.Methods and resultsUsing fresh isolated rat cardiomyocytes, the effects of STC1 on cell hypercontracture, cell shortening and Ca(2+) transients were measured after exposing the cells to ouabain. STC1 alone did not affect cell shortening or the Ca(2+) transient. Exposure to ouabain significantly increased the fraction of hypercontractured cells (40.5+/-1.4% vs 3.5+/-1.7% in the control, p<0.01). However, treatment with STC1 decreased the percentage of cell hypercontracture that was induced by ouabain, in a concentration-dependent manner (17.4+/-2.6% at 2.5 nmol/L STC1, p<0.01). Moreover, STC1 prevented the increase in diastolic intracellular Ca(2+) level that was induced by ouabain (-5.3+/-2.7% vs 7.9+/-3.7% induced by ouabain, p<0.05; -15.3+/-5.1% in the control) in the cardiomyocytes.ConclusionsSTC1 prevented the increase in diastolic Ca(2+) overload and ouabain-induced cell hypercontracture, which suggests that STC1 could effectively prevent cytosolic Ca(2+) overload and protect cardiomyocytes from pathophysiological conditions such as in the failing heart."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.org/dc/terms/identifier | "doi:10.1253/circj.71.796"xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Ishida H."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Nakazawa H."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Ohyama K."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Sugiyama H."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Naito A."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Nakazawa S."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/author | "Hoshiai M."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/name | "Circ J"xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/pages | "796-801"xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/title | "Stanniocalcin 1 prevents cytosolic Ca2+ overload and cell hypercontracture in cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/17457011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17457011 |
| http://purl.uniprot.org/citations/17457011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17457011 |
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| http://purl.uniprot.org/uniprot/#_A0A0H3W641-mappedCitation-17457011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17457011 |
| http://purl.uniprot.org/uniprot/#_P52823-mappedCitation-17457011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17457011 |
| http://purl.uniprot.org/uniprot/#_B2R6I6-mappedCitation-17457011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17457011 |
| http://purl.uniprot.org/uniprot/B2R6I6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17457011 |
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