| http://purl.uniprot.org/citations/17460069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17460069 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145. Exposure of neurons to the neurotoxin ethylcholine aziridinium (AF64A) results in activation of caspase-3 and a dramatic loss of p21(Waf1/Cip1) preceding apoptosis in neurons. These effects of AF64A are reversed by pretreatment with corticosterone. Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase. Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis. We identify p21(Waf1/Cip1) as a novel antiapoptotic factor for postmitotic neurons and implicate p21(Waf1/Cip1) as the molecular target of neuroprotection by high-dose glucocorticoids."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5110-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Hortnagl H."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Endres M."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Harms U."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "von Harsdorf R."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Seidel K."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Albrecht K."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Harms C."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Ruscher K."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Kronenberg G."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Meisel A."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Dirnagl U."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Hauck L."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Hubner D."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/author | "Baldinger T."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/pages | "4562-4571"xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/title | "Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids."xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17460069 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17460069 |
| http://purl.uniprot.org/citations/17460069 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17460069 |