| http://purl.uniprot.org/citations/17463090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17463090 | http://www.w3.org/2000/01/rdf-schema#comment | "S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of the Stat3beta homodimer. S3I-201 inhibits Stat3.Stat3 complex formation and Stat3 DNA-binding and transcriptional activities. Furthermore, S3I-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. Constitutively dimerized and active Stat3C and Stat3 SH2 domain rescue tumor cells from S3I-201-induced apoptosis. Finally, S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo. These findings strongly suggest that the antitumor activity of S3I-201 is mediated in part through inhibition of aberrant Stat3 activation and provide the proof-of-concept for the potential clinical use of Stat3 inhibitors such as S3I-201 in tumors harboring aberrant Stat3."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0609757104"xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Lawrence N.J."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Sebti S.M."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "McLaughlin M.M."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Blaskovich M.A."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Guida W.C."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Jove R."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Turkson J."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Yip M.L."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Greedy B."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Lawrence H.R."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/author | "Siddiquee K."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/pages | "7391-7396"xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/title | "Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity."xsd:string |
| http://purl.uniprot.org/citations/17463090 | http://purl.uniprot.org/core/volume | "104"xsd:string |
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