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| http://purl.uniprot.org/citations/17467122 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders, including Alzheimer's disease. The hypothesis was tested that IL-1 beta renders neurons vulnerable to degeneration by interfering with BDNF-induced neuroprotection. In trophic support-deprived neurons, IL-1 beta compromised the PI3-K/Akt pathway-mediated protection by BDNF and suppressed Akt activation. The effect was specific as in addition to Akt, the activation of MAPK/ERK, but not PLC gamma, was decreased. Activation of CREB, a target of these signaling pathways, was severely depressed by IL-1 beta. As the cytokine did not influence TrkB receptor and PLC gamma activation, IL-1 beta might have interfered with BDNF signaling at the docking step conveying activation to the PI3-K/Akt and Ras/MAPK pathways. Indeed, IL-1 beta suppressed the activation of the respective scaffolding proteins IRS-1 and Shc; this effect might involve ceramide generation. IL-1-induced interference with BDNF neuroprotection and signal transduction was corrected, in part, by ceramide production inhibitors and mimicked by the cell-permeable C2-ceramide. These results suggest that IL-1 beta places neurons at risk by interfering with BDNF signaling involving a ceramide-associated mechanism."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2007.02.027"xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/author | "Cotman C.W."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/author | "Balazs R."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/author | "Thangnipon W."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/author | "Soiampornkul R."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/pages | "1380-1393"xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/title | "Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction."xsd:string |
| http://purl.uniprot.org/citations/17467122 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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