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http://purl.uniprot.org/citations/17470632http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17470632http://www.w3.org/2000/01/rdf-schema#comment"Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRalpha and PDGFRbeta and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease."xsd:string
http://purl.uniprot.org/citations/17470632http://purl.org/dc/terms/identifier"doi:10.1083/jcb.200608093"xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/author"Ball S.G."xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/author"Kielty C.M."xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/author"Shuttleworth C.A."xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/name"J Cell Biol"xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/pages"489-500"xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/title"Vascular endothelial growth factor can signal through platelet-derived growth factor receptors."xsd:string
http://purl.uniprot.org/citations/17470632http://purl.uniprot.org/core/volume"177"xsd:string
http://purl.uniprot.org/citations/17470632http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17470632
http://purl.uniprot.org/citations/17470632http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17470632
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http://purl.uniprot.org/uniprot/P16234#attribution-CB334445DB6AD20A0172626D3947C7DBhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/17470632
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