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| http://purl.uniprot.org/citations/17475835 | http://www.w3.org/2000/01/rdf-schema#comment | "Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune responses in a TLR9-dependent manner. In this study, we found that stimulation of mouse macrophages and dendritic cells with B-type CpG ODN (CpG-B ODN) increased the cellular level of heat shock protein (Hsp) 90beta but not Hsp90alpha and prevented apoptosis induced by serum starvation or staurosporine treatment. The CpG-B ODN-induced Hsp90beta expression depended on TLR9, MyD88, and PI3K. Inhibition of Hsp90beta level by expressing small-interfering RNA suppressed not only Hsp90beta expression but also PI3K-dependent phosphorylation of Akt and CpG-B ODN-mediated antiapoptosis. Additional studies demonstrated that as described by other group in mast cells, Hsp90beta but not Hsp90alpha was associated with Bcl-2. Inhibition of Hsp90beta suppressed the CpG-B ODN-induced association of Hsp90beta with Bcl-2 and impaired the inhibitory effect of CpG-B ODN in the release of cytochrome c and activation of caspase-3. This study thus reveals the involvement of Hsp90beta but not Hsp90alpha in CpG-B ODN-mediated antiapoptotic response and that Hsp90beta is distinct from Hsp90alpha in regulation of the cellular function of immune cells."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6100"xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/author | "Kuo C.C."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/author | "Lai C.Y."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/author | "Liang C.M."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/author | "Liang S.M."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/pages | "6100-6108"xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/title | "Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide."xsd:string |
| http://purl.uniprot.org/citations/17475835 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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