| http://purl.uniprot.org/citations/17507406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17507406 | http://www.w3.org/2000/01/rdf-schema#comment | "The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo. Previous reports have shown that the zebrafish and mouse Cerberus-related proteins Charon and Cerberus-like-2 (Cerl-2), respectively, act in the node region to prevent the Nodal signal from crossing to the right side, whereas chick Cerberus (cCer) has an unclear function in the left-side mesoderm. In this study, we investigate the transcriptional regulation and function of cCer in left-right development. By analyzing the enhancer activity of cCer 5' genomic sequences in electroporated chick embryos, we identified a cCer left-side enhancer that contains two FoxH1 and one SMAD binding site. We show that these Nodal-responsive elements are necessary and sufficient for the activation of transcription in the left-side mesoderm. In transgenic mouse embryos, cCer regulatory sequences behave as in chick embryos, suggesting that the cis-regulatory sequences of Cerberus-related genes have diverged during vertebrate evolution. Moreover, our findings from cCer overexpression and knockdown experiments indicate that cCer is a negative-feedback regulator of Nodal asymmetric signaling. We propose that cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.000901"xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/author | "Belo J.A."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/author | "Silva A.C."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/author | "Andrade S."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/author | "Tavares A.T."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/pages | "2051-2060"xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/title | "Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo."xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/17507406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17507406 |
| http://purl.uniprot.org/citations/17507406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17507406 |
| http://purl.uniprot.org/uniprot/Q9PWB0#attribution-31D88749ADE2D2AAC852B94597B94B0D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/Q9PWB0#attribution-E07CD3B1EB01BBA2CA541E38B4496F17 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/Q8N907#attribution-72CE587134D8CDC30254F62048A05E2D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/O75593#attribution-72CE587134D8CDC30254F62048A05E2D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/P43021#attribution-31D88749ADE2D2AAC852B94597B94B0D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/P43021#attribution-E07CD3B1EB01BBA2CA541E38B4496F17 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/Q76C29#attribution-72CE587134D8CDC30254F62048A05E2D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/#_A0PK81-mappedCitation-17507406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/#_P43021-mappedCitation-17507406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/#_Q76LW6-mappedCitation-17507406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507406 |
| http://purl.uniprot.org/uniprot/#_Q3UPN3-mappedCitation-17507406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507406 |