| http://purl.uniprot.org/citations/17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17525748 | http://www.w3.org/2000/01/rdf-schema#comment | "The chromosomal translocation t(2;13), characteristic for the aggressive childhood cancer alveolar rhabdomyosarcoma (aRMS), generates the chimeric transcription factor PAX3/FKHR with a well known oncogenic role. However, the molecular mechanisms mediating essential pathophysiological functions remain poorly defined. Here, we used comparative expression profiling of PAX3/FKHR silencing in vitro and PAX3/FKHR-specific gene signatures in vivo to identify physiologically important target genes. Hereby, 51 activated genes, both novel and known, were identified. We also found repression of skeletal muscle-specific genes suggesting that PAX3/FKHR blocks further differentiation of aRMS cells. Importantly, TFAP2B was validated as direct target gene mediating the anti-apoptotic function of PAX3/FKHR. Hence, we developed a pathophysiologically relevant transcriptional profile of PAX3/FKHR and identified a critical target gene for aRMS development."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1210525"xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/author | "Schafer B.W."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/author | "Niggli F.K."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/author | "Wachtel M."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/author | "Ebauer M."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/pages | "7267-7281"xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/title | "Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR."xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17525748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17525748 |
| http://purl.uniprot.org/citations/17525748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17525748 |
| http://purl.uniprot.org/uniprot/Q92481#attribution-78BC7CAE0C769FB49AEB81D31A62F3BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/Q92481#attribution-FC7FAB120AD47F42F93B15941F5B01F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/Q61313#attribution-50B213C92C8FA799A3C5A7A5ACDABDA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/Q61313#attribution-FCC43D28F4AF9CCA347FE59B2379AFEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AAN6-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AAN8-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AAQ7-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_E9Q5N4-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_B2R9E2-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_A8K557-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |
| http://purl.uniprot.org/uniprot/#_C7FNH7-mappedCitation-17525748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525748 |