| http://purl.uniprot.org/citations/17543276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17543276 | http://www.w3.org/2000/01/rdf-schema#comment | "Drebrin-A is an actin-binding protein localized in the dendritic spines of mature neurons, and has been suggested to affect spine morphology [K. Hayashi, T. Shirao, Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons, J. Neurosci. 19 (1999) 3918-3925]. However, no biochemical analysis of drebrin-A has yet been reported. In this study, we purified drebrin-A using a bacterial expression system, and characterized it in vitro. Drebrin-A bound to actin filaments with a stoichiometry of one drebrin molecule to 5-6 actin molecules. Furthermore, drebrin-A decreased the Mg-ATPase activity of myosin V. In vitro motility assay revealed that the attachment of F-actin to glass surface coated with myosin-V was decreased by drebrin-A, but once F-actin attached to the surface, the sliding speed of F-actin was unaffected by the presence of drebrin A. These findings suggest that drebrin-A may affect spine dynamics, vesicle transport, and other myosin-V-driven motility in neurons through attenuating the interaction between actin and myosin-V."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.05.123"xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Ishikawa R."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Nakamura A."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Kohama K."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Takahashi A."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Igarashi M."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Katoh K."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/author | "Oseki K."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/pages | "398-401"xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/title | "Drebrin attenuates the interaction between actin and myosin-V."xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://purl.uniprot.org/core/volume | "359"xsd:string |
| http://purl.uniprot.org/citations/17543276 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17543276 |
| http://purl.uniprot.org/citations/17543276 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17543276 |
| http://purl.uniprot.org/uniprot/Q07266#attribution-0D48C3C2E1697B1F57FEAF40DDCE261F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17543276 |
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| http://purl.uniprot.org/uniprot/#_A6KF93-mappedCitation-17543276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17543276 |
| http://purl.uniprot.org/uniprot/#_C6L8E0-mappedCitation-17543276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17543276 |
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| http://purl.uniprot.org/uniprot/#_Q63781-mappedCitation-17543276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17543276 |