| http://purl.uniprot.org/citations/17543862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17543862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17543862 | http://www.w3.org/2000/01/rdf-schema#comment | "Faithful cell-cycle progression is tightly controlled by the ubiquitin-proteasome system. Here we identify a human Cullin 3-based E3 ligase (Cul3) which is essential for mitotic division. In a complex with the substrate-specific adaptors KLHL9 and KLHL13, Cul3 is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. This Cul3-based E3 ligase removes components of the chromosomal passenger complex from mitotic chromosomes and allows their accumulation on the central spindle during anaphase. Aurora B directly binds to the substrate-recognition domain of KLHL9 and KLHL13 in vitro, and coimmunoprecipitates with the Cul3 complex during mitosis. Moreover, Aurora B is ubiquitylated in a Cul3-dependent manner in vivo, and by reconstituted Cul3/KLHL9/KLHL13 ligase in vitro. We thus propose that the Cul3/KLHL9/KLHL13 E3 ligase controls the dynamic behavior of Aurora B on mitotic chromosomes, and thereby coordinates faithful mitotic progression and completion of cytokinesis."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.03.019"xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.03.019"xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Peter M."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Peter M."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Quadroni M."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Quadroni M."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Ricci R."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Ricci R."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Frei C."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Frei C."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Olma M.H."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Olma M.H."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Sumara G."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Sumara G."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Sumara I."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/author | "Sumara I."xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/pages | "887-900"xsd:string |
| http://purl.uniprot.org/citations/17543862 | http://purl.uniprot.org/core/pages | "887-900"xsd:string |