| http://purl.uniprot.org/citations/17600090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17600090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17600090 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs produced during viral replication. In this study, we identified DAK, a functionally unknown dihydroacetone kinase, as a specific MDA5-interacting protein. DAK was associated with MDA5, but not RIG-I, under physiological conditions. Overexpression of DAK inhibited MDA5- but not RIG-I- or TLR3-mediated IFN-beta induction. Overexpression of DAK also inhibited cytoplasmic dsRNA and SeV-induced activation of the IFN-beta promoter, whereas knockdown of endogenous DAK by RNAi activated the IFN-beta promoter, and increased cytoplasmic dsRNA- or SeV-triggered activation of the IFN-beta promoter. In addition, overexpression of DAK inhibited MDA5-but not RIG-I-mediated antiviral activity, whereas DAK RNAi increased cytoplasmic dsRNA-triggered antiviral activity. These findings suggest that DAK is a physiological suppressor of MDA5 and specifically inhibits MDA5-but not RIG-I-mediated innate antiviral signaling."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0700544104"xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0700544104"xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Tien P."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Tien P."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Wang R.P."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Wang R.P."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |
| http://purl.uniprot.org/citations/17600090 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |