| http://purl.uniprot.org/citations/17709599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17709599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17709599 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-8 is a potent neutrophil chemoattractant that drives the inflammatory response in cystic fibrosis (CF). Traditional approaches to the pathophysiology of this inflammation have focused on targeting NF-kappaB-dependent signaling and therapy with glucocorticoids. We test the hypothesis that an alternative pathway, independent of NF-kappaB, operates through prostaglandin E2 (PGE-2) receptor EP-2 and stimulates IL-8 chemokine secretion. Using CF bronchial epithelial cells (IB3-1) in vitro, exogenous PGE-2 induces IL-8 release in a dose-dependent manner. These events are associated with elevation in the EP-2 receptors. Inhibition of cyclooxygenase (Cox)-2 with NS-398 was associated with reductions in Cox-2 (2-fold) and IL-6 (1.3-fold) mRNA transcripts, and in IL-8 and PGE-2 chemokine secretion. The inhibition of Cox-2 signaling led to down-regulation of the downstream C/EBP homologous protein (CHOP) transcription factor, resulting in a decrease in IL-8 activation. We confirmed the regulation of IL-8 promoter by CHOP in CF cells using the IL-8 reporter assay. We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2007-0197oc"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2007-0197oc"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Zeitlin P.L."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Zeitlin P.L."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Amoako M.O."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Amoako M.O."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Mazur S."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Mazur S."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Vij N."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/author | "Vij N."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/name | "Am. J. Respir. Cell Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/name | "Am. J. Respir. Cell Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/pages | "176-184"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/pages | "176-184"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/title | "CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/title | "CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/17709599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17709599 |
| http://purl.uniprot.org/citations/17709599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17709599 |