| http://purl.uniprot.org/citations/17721809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17721809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17721809 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitylation appears to be involved in the membrane trafficking system including endocytosis, exocytosis, and ER-to-Golgi transport. We found that PIRH2, which was identified as an interacting protein for androgen receptor or p53, interacts with and ubiquitylates the epsilon-subunit of coatmer complex, epsilon-COP. PIRH2 promotes the ubiquitylation of epsilon-COP in vitro and in vivo and consequently promotes the degradation of epsilon-COP. The interaction between PIRH2 and epsilon-COP is affected by the presence of androgen, and PIRH2 in the presence of androgen promotes ubiquitylation of epsilon-COP in vivo. Furthermore, overexpression of the wild type of PIRH2 in prostate cancer cells causes downregulation of the secretion of prostate-specific antigen (PSA), a secretory protein in prostate epithelial cells and one of diagnostic markers for prostate cancer. Our results indicate that PIRH2 functions as a regulator for COP I complex."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-007-9586-3"xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-007-9586-3"xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Maruyama S."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Maruyama S."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Miyajima N."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Miyajima N."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Tsukiyama T."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Tsukiyama T."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Bohgaki M."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Bohgaki M."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Nonomura K."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Nonomura K."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Shigemura M."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/author | "Shigemura M."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/pages | "73-82"xsd:string |
| http://purl.uniprot.org/citations/17721809 | http://purl.uniprot.org/core/pages | "73-82"xsd:string |