| http://purl.uniprot.org/citations/17827210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17827210 | http://www.w3.org/2000/01/rdf-schema#comment | "The MED1/TRAP220 subunit of the Mediator plays a key role in facilitating ligand-dependent interactions of this multisubunit coactivator complex with nuclear receptors through their ligand binding domains. The isolated MED1/TRAP220 protein previously was shown to interact with glucocorticoid receptor (GR) in a ligand-dependent manner. However, the functional role of MED1/TRAP220, within the context of the entire Mediator, is not well studied in GR-mediated transcription. In this study, we show that GR binds directly to the Mediator complex and that both LXXLL motifs of MED1/TRAP220 contribute to its binding to GR. Furthermore, using a Med1/Trap220-/-mouse embryonic fibroblast (MEF) line that lacks entirely MED1/TRAP220, we show that MED1/TRAP220 enhances GR-mediated transcription from an MMTV promoter based-reporter gene and that mutations in the MED1/TRAP220 LXXLL motifs reduce, but do not eliminate, GR-dependent transcription. An analysis of endogenous genes in Med1/Trap220-/-cells has confirmed a variable MED1/TRAP220 requirement for different GR target genes. Taken together, these findings support the idea that Mediator, at least in part through MED1/TRAP220, plays a coregulatory role in ligand-dependent GR-mediated gene expression."xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkm661"xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/pages | "6161-6169"xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/title | "The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation."xsd:string |
| http://purl.uniprot.org/citations/17827210 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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