| http://purl.uniprot.org/citations/17917674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17917674 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomerase enables telomere length homeostasis, exhibiting increasing preference for telomeres as their lengths decline. This regulation involves telomere repeat-bound Rap1, which provides a length-dependent negative feedback mechanism, and the Tel1 and Mec1 kinases, which are positive regulators of telomere length. By analysing telomere elongation of wild-type chromosome ends at single-molecule resolution, we show that in tel1Delta cells the overall frequency of elongation decreases considerably, explaining their short telomere phenotype. At an artificial telomere lacking a subtelomeric region, telomere elongation no longer increases with telomere shortening in tel1Delta cells. By contrast, a natural telomere, containing subtelomeric sequence, retains a preference for the elongation of short telomeres. Tethering of the subtelomere binding protein Tbf1 to the artificial telomere in tel1Delta cells restored preferential telomerase action at short telomeres; thus, Tbf1 might function in parallel to Tel1, which has a crucial role in a TG-repeat-controlled pathway for the activation of telomerase at short telomeres."xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7401082"xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/author | "Lingner J."xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/author | "Arneric M."xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/pages | "1080-1085"xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/title | "Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast."xsd:string |
| http://purl.uniprot.org/citations/17917674 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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