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http://purl.uniprot.org/citations/18036345http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18036345http://www.w3.org/2000/01/rdf-schema#comment"Intact osteoactivin, a novel type I membrane glycoprotein, were shed at a dibasic motif in the juxtamembrane region in C2C12 myoblasts. Extracellular fragments were secreted into the culture media by a putative metalloprotease. Extracellular fragments of osteoactivin, but not control protein, induced matrix metalloprotease-3 (MMP-3) expression in NIH-3T3 fibroblasts. Epidermal growth factor (ERK) kinase inhibitors inhibited the osteoactivin-mediated MMP-3 expression, whereas the extracellular fragment of osteoactivin activated ERK1/2 and p38 in the mitogen-activated protein kinase pathway. Our results suggest that the extracellular fragments of osteoactivin produced by shedding act as a growth factor to induce MMP-3 expression via the ERK pathway in fibroblasts."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2007.11.036"xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Ogawa T."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Yamada C."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Oguri S."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Tamura S."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Higashiyama S."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Okumura Y."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Imagawa T."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Kishi K."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Ishidoh K."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Nikawa T."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Hirasaka K."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Furochi H."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/author"Mameoka M."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/pages"5743-5750"xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/title"Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts."xsd:string
http://purl.uniprot.org/citations/18036345http://purl.uniprot.org/core/volume"581"xsd:string
http://purl.uniprot.org/citations/18036345http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18036345
http://purl.uniprot.org/citations/18036345http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18036345
http://purl.uniprot.org/uniprot/Q99P91#attribution-54D1D55B54F16276F9D83CA171EC958Ahttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/18036345
http://purl.uniprot.org/uniprot/#_A0A0N4SVG5-mappedCitation-18036345http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18036345