| http://purl.uniprot.org/citations/18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18055550 | http://www.w3.org/2000/01/rdf-schema#comment | "IGSF4a/RA175/SynCAM (RA175) and junctional adhesion molecules (Jams) are members of the immunoglobulin superfamily with a PDZ-binding domain at their C termini. Deficiency of Ra175 (Ra175(-/-)) as well as Jam-C deficiency (Jam-C(-/-)) causes the defect of the spermatid differentiation, oligo-astheno-teratozoospermia. Ra175(-/-) elongating spermatids fail to mature further, whereas Jam-C(-/-) round spermatids lose cell polarity, and most of Jam-C(-/-) elongated spermatids are completely lost. RA175 and Jam-C seem to have similar but distinct functional roles during spermatid differentiation. Here we show that the cell polarity protein Par-3 with PDZ domains, a binding partner of Jams, is one of the associated proteins of the cytoplasmic region of RA175 in testis. Par-3 and Jam-C are partly co-localized with RA175 in the elongating and elongated spermatids; their distributions overlapped with that of RA175 on the tips of the dorsal region of the head of the elongating spermatid (steps 9 to 12) in the wild type. In the Ra175(-/-) elongating spermatid, Par-3 was absent, and Jam-C was absent or abnormally localized. The RA175 formed a ternary complex with Jam-C via interaction with Par-3. The lack of the ternary complex in the Ra175(-/-) elongating spermatid may cause the defect of the specialized adhesion structures, resulting in the oligo-astheno-teratozoospermia."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2007.070261"xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Hirose T."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Tanabe Y."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Kasahara T."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Imhof B.A."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Momoi T."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Fujita E."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/author | "Aurrand-Lions M."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/pages | "1800-1810"xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/title | "Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/18055550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18055550 |
| http://purl.uniprot.org/citations/18055550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18055550 |
| http://purl.uniprot.org/uniprot/Q8R5M8#attribution-E92C499CD333B47C306C8662BDDC9DEE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18055550 |
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| http://purl.uniprot.org/uniprot/#_E0CXR8-mappedCitation-18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055550 |
| http://purl.uniprot.org/uniprot/#_E0CY16-mappedCitation-18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055550 |
| http://purl.uniprot.org/uniprot/#_E0CY24-mappedCitation-18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055550 |
| http://purl.uniprot.org/uniprot/#_E0CYB6-mappedCitation-18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055550 |
| http://purl.uniprot.org/uniprot/#_E0CZ83-mappedCitation-18055550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055550 |