| http://purl.uniprot.org/citations/18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18097009 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcineurin (Cn) is a Ca2+/calmodulin-dependent phosphatase that dephosphorylates and activates NFAT, a transcription factor essential for T cell activation. T lymphocytes predominantly express the calcineurin Abeta (CnAbeta) isoform, and the deletion of the CnAbeta gene results in defective T cell proliferation and IL-2 production in response to TCR stimulation. In this study, we show that CnAbeta enhances the spontaneous survival of naive T cells by maintaining high levels of Bcl-2, a critical homeostatic survival factor for naive T cells. T cells obtained from CnAbeta-/-mice displayed accelerated spontaneous apoptosis. The observed apoptosis of the CnAbeta-/-T cells was prevented by IL-7 and IL-15, two cytokines critical for the homeostatic survival of naive T cells. Furthermore, CD4+ or CD8+ single positive CnAbeta-/-thymocytes also underwent accelerated apoptosis. However, no obvious difference in the apoptosis of CD4+CD8+ double positive thymocytes was observed between CnAbeta-/- and wild-type mice, suggesting a specific function of CnAbeta in the survival of single positive T cells. Bcl-2 levels were found to be significantly lower in CnAbeta-/-T cells. Transgenic expression of Bcl-xL restored the survival of the CnAbeta-/-T cells. Thus, in addition to its role in mediating TCR signals essential for T cell activation, CnAbeta is also required for the homeostatic survival of naive T cells."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.1.106"xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Shang W."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/author | "Manicassamy S."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/pages | "106-112"xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/title | "Requirement of calcineurin a beta for the survival of naive T cells."xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18097009 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18097009 |
| http://purl.uniprot.org/citations/18097009 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18097009 |
| http://purl.uniprot.org/uniprot/P48453#attribution-16E4DA85DBEDC1D4DF7D1A3CA0CD7A8E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18097009 |
| http://purl.uniprot.org/uniprot/#_E0CZ78-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |
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| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ8-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |
| http://purl.uniprot.org/uniprot/#_A0A6B9EQU3-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |
| http://purl.uniprot.org/uniprot/#_G3X8U7-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |
| http://purl.uniprot.org/uniprot/#_P10168-mappedCitation-18097009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097009 |