| http://purl.uniprot.org/citations/18177722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18177722 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals use the insulin/TOR signaling pathway to mediate their response to fluctuations in nutrient availability. Energy and amino acids are monitored at the single-cell level via the TOR branch of the pathway and systemically via insulin signaling to regulate cellular growth and metabolism. Using a combination of genetics, expression profiling, and chromatin immunoprecipitation, we examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. We also identify myc as a direct target of FOXO and provide genetic evidence that Myc has a key role in mediating the effects of TOR and FOXO on growth and metabolism. FOXO and TOR also converge to regulate protein synthesis, acting via 4E-BP and Lk6, regulators of the translation factor eIF4E. This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2007.11.010"xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/author | "Hietakangas V."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/author | "Teleman A.A."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/author | "Cohen S.M."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/author | "Sayadian A.C."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/pages | "21-32"xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/title | "Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/18177722 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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| http://purl.uniprot.org/uniprot/Q95V55#attribution-E79A57589294F43A99A6CF670CACE9E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18177722 |
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