| http://purl.uniprot.org/citations/18184661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18184661 | http://www.w3.org/2000/01/rdf-schema#comment | "The bone morphogenetic protein (BMP) family, the largest subfamily of the structurally conserved transforming growth factor-beta (TGF-beta) superfamily of growth factors, are multifunctional regulators of development, proliferation, and differentiation. The TGF-beta type III receptor (TbetaRIII or betaglycan) is an abundant cell surface proteoglycan that has been well characterized as a TGF-beta and inhibin receptor. Here we demonstrate that TbetaRIII functions as a BMP cell surface receptor. TbetaRIII directly and specifically binds to multiple members of the BMP subfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains as previously identified for TGF-beta. TbetaRIII also enhances ligand binding to the BMP type I receptors, whereas short hairpin RNA-mediated silencing of endogenous TbetaRIII attenuates BMP-mediated Smad1 phosphorylation. Using a biologically relevant model for TbetaRIII function, we demonstrate that BMP-2 specifically stimulates TbetaRIII-mediated epithelial to mesenchymal cell transformation. The ability of TbetaRIII to serve as a cell surface receptor and mediate BMP, inhibin, and TGF-beta signaling suggests a broader role for TbetaRIII in orchestrating TGF-beta superfamily signaling."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704883200"xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/author | "Barnett J.V."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/author | "Blobe G.C."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/author | "Kirkbride K.C."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/author | "Bruinsma M.W."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/author | "Townsend T.A."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/pages | "7628-7637"xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/title | "Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor."xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18184661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18184661 |
| http://purl.uniprot.org/citations/18184661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18184661 |
| http://purl.uniprot.org/uniprot/P36894#attribution-4BD87602BE66469746838C2F7A2E3EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/O00238#attribution-4BD87602BE66469746838C2F7A2E3EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/O00238#attribution-4DF205728C33F461D85D95997FFD714D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/P12643#attribution-4DF205728C33F461D85D95997FFD714D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/P18075#attribution-4BD87602BE66469746838C2F7A2E3EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/Q03167#attribution-4BD87602BE66469746838C2F7A2E3EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/Q03167#attribution-4DF205728C33F461D85D95997FFD714D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/#_A0A0A8KWK3-mappedCitation-18184661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/#_Q03167-mappedCitation-18184661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18184661 |
| http://purl.uniprot.org/uniprot/Q03167 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18184661 |