| http://purl.uniprot.org/citations/18185515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18185515 | http://www.w3.org/2000/01/rdf-schema#comment | "There are fundamental similarities between sleep in mammals and quiescence in the arthropod Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient. The nematode Caenorhabditis elegans also has a quiescent behavioural state during a period called lethargus, which occurs before each of the four moults. Like sleep, lethargus maintains a constant temporal relationship with the expression of the C. elegans Period homologue LIN-42 (ref. 5). Here we show that quiescence associated with lethargus has the additional sleep-like properties of reversibility, reduced responsiveness and homeostasis. We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sensory neurons to promote the C. elegans sleep-like state. Conserved effects on sleep-like behaviour of homologous genes in C. elegans and Drosophila suggest a common genetic regulation of sleep-like states in arthropods and nematodes. Our results indicate that C. elegans is a suitable model system for the study of sleep regulation. The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06535"xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Sundaram M.V."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Raizen D.M."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Pack A.I."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "You Y.J."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Zimmerman J.E."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Maycock M.H."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/author | "Ta U.D."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/pages | "569-572"xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/title | "Lethargus is a Caenorhabditis elegans sleep-like state."xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://purl.uniprot.org/core/volume | "451"xsd:string |
| http://purl.uniprot.org/citations/18185515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18185515 |
| http://purl.uniprot.org/citations/18185515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18185515 |
| http://purl.uniprot.org/uniprot/O76360#attribution-0F106979DB4180E8CD497C13BCDBDB1B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/Q22000#attribution-0F106979DB4180E8CD497C13BCDBDB1B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/Q19523#attribution-0F106979DB4180E8CD497C13BCDBDB1B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/Q2V4U0#attribution-0F106979DB4180E8CD497C13BCDBDB1B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/#_S6FCW6-mappedCitation-18185515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/#_Q19523-mappedCitation-18185515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/#_Q22000-mappedCitation-18185515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18185515 |
| http://purl.uniprot.org/uniprot/#_O76360-mappedCitation-18185515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18185515 |