| http://purl.uniprot.org/citations/18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18190519 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the gene for parkin, a 52-kDa E3 ubiquitin ligase, are a major cause of hereditary Parkinson's disease (PD). In vitro studies have identified a large number of parkin-interacting proteins. Whether parkin exists as a monomer or as part of a stable protein complex in vivo is uncertain. Here we demonstrate that endogenous parkin occurs in a stable, non-covalent, approximately 110-kDa complex in native extracts from mouse brain, heart and skeletal muscle, while monomeric parkin is undetectable. Partial denaturation experiments indicate that this complex is at least a tetramer. Reported parkin-binding partners do not show detectable association with the parkin complex on native gels. Upon overexpression in COS1, SH-SY5Y or CHO cells, parkin accumulates predominantly as a monomer, suggesting that the interactors required for complex formation are available in limiting amounts in these cells. Importantly, PD-linked parkin mutations significantly impair parkin complex formation. These data demonstrate that parkin oligomerizes into a stable, non-covalent, heteromeric complex in vivo, and suggest that parkin may have as yet unidentified stable binding partners."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2007.06000.x"xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/author | "Waelkens E."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/author | "Brice A."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/author | "Van Humbeeck C."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/author | "Vandenberghe W."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/author | "Corti O."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/pages | "284-293"xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/title | "Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain."xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18190519 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18190519 |
| http://purl.uniprot.org/citations/18190519 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18190519 |
| http://purl.uniprot.org/uniprot/P23819#attribution-F63D1723179479CAC380F6542A44EE2D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/Q9WVS6#attribution-F63D1723179479CAC380F6542A44EE2D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW90-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_A0A087WQJ2-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W3P9-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W489-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7W2-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_C9K0Z0-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_C9K0Z1-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |
| http://purl.uniprot.org/uniprot/#_B8YP88-mappedCitation-18190519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18190519 |