| http://purl.uniprot.org/citations/18193033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18193033 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant Wnt signalling promotes oncogenesis by increasing the nuclear accumulation of beta-catenin to activate downstream target genes. However, the mechanism of beta-catenin recruitment to the Wnt target-gene promoter, a critical step for removing the co-repressor complex, is largely unknown. Here, we report that transducin beta-like protein 1 (TBL1) and its highly related family member TBLR1 were required for Wnt-beta-catenin-mediated transcription. Wnt signalling induced the interaction between beta-catenin and TBL1-TBLR1, as well as their binding to Wnt target genes. Importantly, the recruitment of TBL1-TBLR1 and beta-catenin to Wnt target-gene promoters was mutually dependent on each other. Furthermore, the depletion of TBL1-TBLR1 significantly inhibited Wnt-beta-catenin-induced gene expression and oncogenic growth in vitro and in vivo. Our results unravel two new components required for nuclear beta-catenin function, and have important implications in developing new strategies for inhibiting Wnt-beta-catenin-mediated tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1684"xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/author | "Wang C.Y."xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/pages | "160-169"xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/title | "TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/18193033 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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| http://purl.uniprot.org/citations/18193033 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18193033 |
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| http://purl.uniprot.org/uniprot/Q9BZK7#attribution-968943528206F685D448770725C86D9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18193033 |
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| http://purl.uniprot.org/uniprot/O60907#attribution-36CE5243339AC17D131C6D007C59B5D5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18193033 |
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