| http://purl.uniprot.org/citations/18218901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18218901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18218901 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell receptor (TCR) and costimulatory receptor (CD28) signals cooperate in activating T cells, although understanding of how these pathways are themselves regulated is incomplete. We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation. This is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin. Homer-NFAT binding was also antagonized by active serine-threonine kinase AKT, thereby enhancing TCR signaling via calcineurin-dependent dephosphorylation of NFAT. This corresponded with changes in cytokine expression and an increase in effector-memory T cell populations in Homer-deficient mice, which also developed autoimmune-like pathology. These results demonstrate a further means by which costimulatory signals are regulated to control self-reactivity."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1151227"xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1151227"xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "May M.J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "May M.J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Lutz M."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Lutz M."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Collins S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Collins S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Powell J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Powell J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Tu J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Tu J."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Bouyain S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Bouyain S."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Dehoff M."xsd:string |
| http://purl.uniprot.org/citations/18218901 | http://purl.uniprot.org/core/author | "Dehoff M."xsd:string |