| http://purl.uniprot.org/citations/18219313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18219313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18219313 | http://www.w3.org/2000/01/rdf-schema#comment | "NOD-like receptors (NLRs) are a family of intracellular sensors of microbial- or danger-associated molecular patterns. Here, we report the identification of NLRX1, which is a new member of the NLR family that localizes to the mitochondria. NLRX1 alone failed to trigger most of the common signalling pathways, including nuclear factor-kappaB (NF)-kappaB- and type I interferon-dependent cascades, but could potently trigger the generation of reactive oxygen species (ROS). Importantly, NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling. Together, these results identify NLRX1 as a NLR that contributes to the link between ROS generation at the mitochondria and innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7401161"xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7401161"xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Arnoult D."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Arnoult D."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Carneiro L.A."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Carneiro L.A."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Girardin S.E."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Girardin S.E."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Magalhaes J.G."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Magalhaes J.G."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Shu Y."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Shu Y."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Jehanno M."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Jehanno M."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Tattoli I."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/author | "Tattoli I."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/18219313 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |