| http://purl.uniprot.org/citations/18243112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18243112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18243112 | http://www.w3.org/2000/01/rdf-schema#comment | "The ATPase RIG-I senses viral RNAs that contain 5'-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host. The mode of RNA 5'-triphosphate sensing by RIG-I remains elusive. We show that the C-terminal regulatory domain RD of RIG-I binds viral RNA in a 5'-triphosphate-dependent manner and activates the RIG-I ATPase by RNA-dependent dimerization. The crystal structure of RD reveals a zinc-binding domain that is structurally related to GDP/GTP exchange factors of Rab-like GTPases. The zinc coordination site is essential for RIG-I signaling and is also conserved in MDA5 and LGP2, suggesting related RD domains in all three enzymes. Structure-guided mutagenesis identifies a positively charged groove as likely 5'-triphosphate-binding site of RIG-I. This groove is distinct in MDA5 and LGP2, raising the possibility that RD confers ligand specificity."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.10.032"xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.10.032"xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Cui S."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Cui S."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Krug A."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Krug A."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Hopfner K.-P."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Hopfner K.-P."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Conzelmann K.-K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Conzelmann K.-K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Lammens A."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Lammens A."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Brzozka K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Brzozka K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Lammens K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Lammens K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Eisenaecher K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Eisenaecher K."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Kirchhofer A."xsd:string |
| http://purl.uniprot.org/citations/18243112 | http://purl.uniprot.org/core/author | "Kirchhofer A."xsd:string |