| http://purl.uniprot.org/citations/18249187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18249187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18249187 | http://www.w3.org/2000/01/rdf-schema#comment | "Sirt2 is a mammalian member of the Sirtuin family of NAD(+) (nicotinamide adenine dinucleotide)-dependent protein deacetylases. Although Sir-2.1 (a Caenorhabditis elegans Sirt2 ortholog) has been reported to interact with PAR-5/FTT-2 (a C. elegans 14-3-3 homolog), the molecular significance of the interaction between Sirt2 and 14-3-3 proteins in mammalian cell is not understood. Here, we report that Sirt2 interacts with 14-3-3 beta and gamma among various 14-3-3 isoforms, and that this interaction is strengthened by AKT. Furthermore, Sirt2 deacetylates and down-regulates the transcriptional activity of p53, and 14-3-3 beta/gamma augment deacetylation and down-regulation of the p53 transcriptional activity by Sirt2 in an AKT-dependent manner. Treatment of cells with nicotinamide, an inhibitor of Sirtuins, relieves the inhibition of p53 by Sirt2 and 14-3-3 beta/gamma. Therefore, our results suggest that the interaction between Sirt2 and 14-3-3 beta/gamma is a novel mechanism for the negative regulation of p53 beside the well-characterized Mdm2-mediated repression."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.01.114"xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.01.114"xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Baek K.H."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Baek K.H."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Jin Y.H."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Jin Y.H."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kang B.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kang B.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Yeo C.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/author | "Yeo C.Y."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/pages | "690-695"xsd:string |
| http://purl.uniprot.org/citations/18249187 | http://purl.uniprot.org/core/pages | "690-695"xsd:string |