| http://purl.uniprot.org/citations/18253931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18253931 | http://www.w3.org/2000/01/rdf-schema#comment | "Mediator release from mast cells (MC) is a crucial step in allergic and non-allergic inflammatory disorders. However, the final events in response to activation leading to membrane fusion and thereby facilitating degranulation have hitherto not been analyzed in human MC. Soluble N-ethyl-maleimide-sensitive factor attachment protein receptors (SNARE) represent a highly conserved family of proteins that have been shown to mediate intracellular membrane fusion events. Here, we show that mature MC isolated from human intestinal tissue express soluble N-ethylmaleide sensitive factor attachment protein (SNAP)-23, Syntaxin (STX)-1B, STX-2, STX-3, STX-4, and STX-6 but not SNAP-25. Furthermore, we found that primary human MC express substantial amounts of vesicle associated membrane protein (VAMP)-3, VAMP-7 and VAMP-8 and, in contrast to previous reports about rodent MC, only low levels of VAMP-2. Furthermore, VAMP-7 and VAMP-8 were found to translocate to the plasma membrane and interact with SNAP-23 and STX-4 upon activation. Inhibition of SNAP-23, STX-4, VAMP-7 or VAMP-8, but not VAMP-2 or VAMP-3, resulted in a markedly reduced high-affinity IgE receptor-mediated histamine release. In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737634"xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Bigalke H."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Galli T."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Bolat S."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Lorentz A."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Blank U."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Bischoff S.C."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Sander L.E."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/author | "Frank S.P."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/pages | "855-863"xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/title | "Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells."xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/18253931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18253931 |
| http://purl.uniprot.org/citations/18253931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18253931 |
| http://purl.uniprot.org/uniprot/O95219#attribution-0E588F445DF45ABBDB2ADE3D584F1B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/O95219#attribution-75E1F654EDB86A8E22EDFD650BE75075 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/O00161#attribution-0E588F445DF45ABBDB2ADE3D584F1B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/O00161#attribution-75E1F654EDB86A8E22EDFD650BE75075 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/P51809#attribution-0E588F445DF45ABBDB2ADE3D584F1B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/P51809#attribution-75E1F654EDB86A8E22EDFD650BE75075 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |
| http://purl.uniprot.org/uniprot/Q9BV40#attribution-0E588F445DF45ABBDB2ADE3D584F1B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18253931 |