| http://purl.uniprot.org/citations/18289868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18289868 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-32 was recently identified as a new cytokine which induces various proinflammatory cytokines in human monocytes and macrophages. Therefore, IL-32 has been primarily studied in inflammatory models such as rheumatoid arthritis and inflammatory bowel diseases. The regulation of endogenous IL-32 in other immune cells remains unknown. In the present study, we stimulated Jurkat T cells with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) and examined IL-32 expression at both the mRNA and protein levels. All mRNAs of the four IL-32 isoforms and the 12-15 kDa IL-32 protein were independent of PHA and PMA stimulation, however a 9 kDa molecular weight IL-32 protein in the cell culture supernatant was induced by PHA and PMA after 16 h of stimulation. Compared to other human cell lines, the Jurkat cell line constitutively expressed a 12-15 kDa molecule of IL-32, which is smaller than the known IL-32 isoforms. We used IL-32 shRNA to examine the specificity of the 12-15 kDa molecule. Upon IL-32 shRNA transfection, the 12-15 kDa band was decreased specifically as compared to the control scrambled clone. Thus, the constitutive expression of IL-32 mRNA as well as the predominant production of a smaller sized IL-32 isoform in Jurkat cells may implicate a role for IL-32 in human T cell leukemia."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2008.01.004"xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Chang S.H."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Hong J.W."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Choi J.D."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Choi W.S."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Bae S.Y."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Her E."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Azam T."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Kim N.W."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Ko N.Y."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/author | "Jaekal J."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/pages | "121-127"xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/title | "Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line."xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/18289868 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18289868 |
| http://purl.uniprot.org/citations/18289868 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18289868 |
| http://purl.uniprot.org/uniprot/#_C6GKH1-mappedCitation-18289868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18289868 |
| http://purl.uniprot.org/uniprot/#_C6GKH2-mappedCitation-18289868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18289868 |