| http://purl.uniprot.org/citations/18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292548 | http://www.w3.org/2000/01/rdf-schema#comment | "Death-associated protein kinase (DAPK) is a unique multidomain kinase acting both as a tumor suppressor and an apoptosis inducer. The molecular mechanism underlying the effector function of DAPK is not fully understood, while the role of DAPK in T lymphocyte activation is mostly unknown. DAPK was activated after TCR stimulation. Through the expression of a dominant-negative and a constitutively active form of DAPK in T cells, we found that DAPK negatively regulated T cell activation. DAPK markedly affected T cell proliferation and IL-2 production. We identified TCR-induced NF-kappaB activation as a target of DAPK. In contrast, IL-1beta- and TNF-alpha-triggered NF-kappaB activation was not affected by DAPK. We further found that DAPK selectively modulated the TCR-induced translocation of protein kinase Ctheta, Bcl-10, and IkappaB kinase into membrane rafts. Notably, the effect of DAPK on the raft entry was specific for the NF-kappaB pathway, as other raft-associated molecules, such as linker for activation of T cells, were not affected. Our results clearly demonstrate that DAPK is a novel regulator targeted to TCR-activated NF-kappaB and T cell activation."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.5.3238"xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/author | "Lai M.Z."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/author | "Chuang Y.T."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/author | "Fang L.W."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/author | "Lin-Feng M.H."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/pages | "3238-3249"xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/title | "The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation."xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18292548 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18292548 |
| http://purl.uniprot.org/citations/18292548 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18292548 |
| http://purl.uniprot.org/uniprot/#_A0A286YDD8-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_A0T398-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_B7Z454-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_B4DHI4-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_P53355-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_Q3UKP8-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_Q80YE7-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/#_Q59H88-mappedCitation-18292548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/P53355 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18292548 |
| http://purl.uniprot.org/uniprot/B4DHI4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18292548 |