| http://purl.uniprot.org/citations/18304746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18304746 | http://www.w3.org/2000/01/rdf-schema#comment | "Migrating neuroblasts in the adult brain form the rostral migratory stream (RMS) from the lateral ventricle to the olfactory bulb (OB) and then differentiate in the OB. In this study, we immunohistochemically analyzed drebrin expression in the RMS of the adult rat brain. Although drebrin is concentrated in dendritic spines of mature neurons, drebrin-immunopositive (DIP) cell bodies were observed in the RMS. The polysialated form of a neural cell adhesion molecule (PSA-NCAM) was detected in DIP cells. K(i)-67, a marker of proliferating cells, was also detected in a subset of DIP cells; however, neither glial fibrillary acidic protein, nestin nor vimentin was detected in DIP cells. These results indicate that DIP cells in the RMS are migrating neuroblasts. An image subtraction method, based on using anti-pan-drebrin and anti-drebrin A antibodies, demonstrated that DIP migrating neuroblasts are immunopositive for drebrin E but not for drebrin A (E+A-). Furthermore, olfactory bulbectomy increased the number of cells with drebrin E+A-signals in the RMS, indicating that these cells migrate along the RMS. Drebrin E+A-cells were also found in the subgranular layer of the dentate gyrus and in the piriform cortex. Thus, detection of drebrin E+A-signals is useful for identifying migrating neuroblasts in the adult brain. In the OB, drebrin E+A-signals were observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A-signals were observed in postmigratory neuroblasts at the outer layers. These data demonstrate that the disappearance of drebrin E+A-signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2007.10.068"xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Kojima N."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Sekino Y."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Mikuni M."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Shirao T."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Hanamura K."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/author | "Inoue H.K."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/pages | "670-682"xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/title | "Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration."xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/18304746 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18304746 |
| http://purl.uniprot.org/citations/18304746 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18304746 |
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