| http://purl.uniprot.org/citations/18309324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18309324 | http://www.w3.org/2000/01/rdf-schema#comment | "As a result of the genetic experiments performed in Caenorhabditis elegans, it has been tacitly assumed that the core proteins of the 'apoptotic machinery' (CED-3, -4, -9 and EGL-1) would be solely involved in cell death regulation/execution and would not exert any functions outside of the cell death realm. However, multiple studies indicate that the mammalian orthologs of these C. elegans proteins (i.e. caspases, Apaf-1 and multidomain proteins of the Bcl-2 family) participate in cell death-unrelated processes. Similarly, loss-of-function mutations of ced-4 compromise the mitotic arrest of DNA-damaged germline cells from adult nematodes, even in a context in which the apoptotic machinery is inoperative (for instance due to mutations of egl-1 or ced-3). Moreover, EGL-1 is required for the activation of autophagy in starved nematodes. Finally, the depletion of caspase-independent death effectors, such as apoptosis-inducing factor (AIF) and endonuclease G, provokes cell death-independent consequences, both in mammals and in yeast (Saccharomyces cerevisiae). These results corroborate the conjecture that any kind of protein that has previously been specifically implicated in apoptosis might have a phylogenetically conserved apoptosis-unrelated function, most likely as part of an adaptive response to cellular stress."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2008.28"xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Madeo F."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Tavernarakis N."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Abrams J.M."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Joza N."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Penninger J."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Galluzzi L."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Maiuri M.C."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Tasdemir E."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/author | "Hengartner M."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/pages | "1113-1123"xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/title | "No death without life: vital functions of apoptotic effectors."xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/18309324 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18309324 |
| http://purl.uniprot.org/citations/18309324 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18309324 |
| http://purl.uniprot.org/uniprot/Q9Z0X1#attribution-139BD46EC024A4D1AB0913E2C05AE874 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18309324 |
| http://purl.uniprot.org/uniprot/O95831#attribution-139BD46EC024A4D1AB0913E2C05AE874 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18309324 |
| http://purl.uniprot.org/uniprot/O14727#attribution-139BD46EC024A4D1AB0913E2C05AE874 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18309324 |
| http://purl.uniprot.org/uniprot/Q92934#attribution-139BD46EC024A4D1AB0913E2C05AE874 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18309324 |
| http://purl.uniprot.org/uniprot/P10415#attribution-139BD46EC024A4D1AB0913E2C05AE874 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18309324 |