| http://purl.uniprot.org/citations/18321983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18321983 | http://www.w3.org/2000/01/rdf-schema#comment | "The endocycle is a commonly observed variant cell cycle in which cells undergo repeated rounds of DNA replication with no intervening mitosis. How the cell cycle machinery is modified to transform a mitotic cycle into endocycle has long been a matter of interest. In both plants and animals, the transition from the mitotic cycle to the endocycle requires Fzr/Cdh1, a positive regulator of the Anaphase-Promoting Complex/Cyclosome (APC/C). However, because many of its targets are transcriptionally downregulated upon entry into the endocycle, it remains unclear whether the APC/C functions beyond the mitotic/endocycle boundary. Here, we report that APC/C Fzr/Cdh1 activity is required to promote the G/S oscillation of the Drosophila endocycle. We demonstrate that compromising APC/C activity, after cells have entered the endocycle, inhibits DNA replication and results in the accumulation of multiple APC/C targets, including the mitotic cyclins and Geminin. Notably, our data suggest that the activity of APC/C Fzr/Cdh1 during the endocycle is not continuous but is cyclic, as demonstrated by the APC/C-dependent oscillation of the pre-replication complex component Orc1. Taken together, our data suggest a model in which the cyclic activity of APC/C Fzr/Cdh1 during the Drosophila endocycle is driven by the periodic inhibition of Fzr/Cdh1 by Cyclin E/Cdk2. We propose that, as is observed in mitotic cycles, during endocycles, APC/C Fzr/Cdh1 functions to reduce the levels of the mitotic cyclins and Geminin in order to facilitate the relicensing of DNA replication origins and cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.016295"xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Asano M."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Pal M."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Lilly M.A."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Deak P."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Richardson H.E."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Herr A."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Senger S."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/author | "Narbonne-Reveau K."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/pages | "1451-1461"xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/title | "APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle."xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18321983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18321983 |
| http://purl.uniprot.org/citations/18321983 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18321983 |
| http://purl.uniprot.org/uniprot/Q9V831#attribution-E697E0122BEA00D97534FFDF786541A6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/Q7JX41#attribution-47F9F7DC48D4829C915C20230CF7074E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/Q9I7L8#attribution-47F9F7DC48D4829C915C20230CF7074E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-18321983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/#_M9NFR3-mappedCitation-18321983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/#_O18402-mappedCitation-18321983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18321983 |
| http://purl.uniprot.org/uniprot/#_O96679-mappedCitation-18321983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18321983 |