| http://purl.uniprot.org/citations/18323775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18323775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18323775 | http://www.w3.org/2000/01/rdf-schema#comment | "The Golgi apparatus occupies a central position within the secretory pathway, but the molecular mechanisms responsible for its assembly and organization remain poorly understood. We report here the identification of zinc finger protein-like 1 (ZFPL1) as a novel structural component of the Golgi apparatus. ZFPL1 is a conserved and widely expressed integral membrane protein with two predicted zinc fingers at the N-terminus, the second of which is a likely ring domain. ZFPL1 directly interacts with the cis-Golgi matrix protein GM130. Depletion of ZFPL1 results in the accumulation of cis-Golgi matrix proteins in the intermediate compartment (IC) and the tubulation of cis-Golgi and IC membranes. Loss of ZFPL1 function also impairs cis-Golgi assembly following brefeldin A washout and slows the rate of cargo trafficking into the Golgi apparatus. Effects upon Golgi matrix protein localization and cis-Golgi structure can be rescued by wild-type ZFPL1 but not mutants defective in GM130 binding. Together, these data suggest that ZFPL1 has an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GM130."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.40"xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.40"xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Diao A."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Diao A."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Lowe M."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Lowe M."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "McKenzie E."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "McKenzie E."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Chiu C.-F."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Chiu C.-F."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Frost L."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Frost L."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Ghanekar Y."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Ghanekar Y."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Morrison D."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/author | "Morrison D."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/pages | "934-947"xsd:string |
| http://purl.uniprot.org/citations/18323775 | http://purl.uniprot.org/core/pages | "934-947"xsd:string |