| http://purl.uniprot.org/citations/18349073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18349073 | http://www.w3.org/2000/01/rdf-schema#comment | "CD47 and SHPS-1 are transmembrane proteins that interact with each other through their extracellular regions and constitute a bidirectional cell-cell communication system (the CD47-SHPS-1 system). We have now shown that the trans-interaction of CD47 and SHPS-1 that occurred on contact of CD47-expressing CHO cells and SHPS-1-expressing CHO cells resulted in endocytosis of the ligand-receptor complex into either cell type. Such trans-endocytosis of CD47 by SHPS-1-expressing cells was found to be mediated by clathrin and dynamin. A juxtamembrane region of SHPS-1 was indispensable for efficient trans-endocytosis of CD47, which was also regulated by Rac and Cdc42, probably through reorganization of the actin cytoskeleton. Inhibition of trans-endocytosis of CD47 promoted the aggregation of CD47-expressing cells with the cells expressing SHPS-1. Moreover, CD47 expressed on the surface of cultured mouse hippocampal neurons was shown to undergo trans-endocytosis by neighboring astrocytes expressing endogenous SHPS-1. These results suggest that trans-endocytosis of CD47 is responsible for removal of the CD47-SHPS-1 complex from the cell surface and hence regulates the function of the CD47-SHPS-1 system, at least in neurons and glial cells."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.025015"xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Murata T."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Murata Y."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Jin F.J."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Okazawa H."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Kusakari S."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/author | "Matozaki T."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/pages | "1213-1223"xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/title | "Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system."xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/18349073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18349073 |
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| http://purl.uniprot.org/uniprot/#_A0A2R8VK70-mappedCitation-18349073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18349073 |
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